Selank
Selank is a synthetic analogue of the immune peptide tuftsin, developed in Russia and studied there as an anxiolytic, with essentially no Western regulatory recognition.
Regulatory status: Registered and used in Russia; not FDA-approved and not reviewed by the EMA. The evidence base is dominated by Russian research groups.
Default vial
10 mg
Default mix
2 mL
Reported range
250–500 mcg
Draw (U-100)
6 u
Anxiolytic tuftsin analog, most often used intranasally in 10–14 day blocks.
Where these numbers come from
Selank is registered in Russia as an intranasal product with its own instructions for use; those numbers are not equivalent to the subcutaneous figures circulated online, so treat these as convention.
Reviewed August 2026
What it is
- A synthetic heptapeptide analogue of tuftsin.
- Proposed mechanisms in the Russian pharmacology literature involve BDNF regulation in the hippocampus and prefrontal cortex and inhibition of enkephalin-degrading enzymes.
- Studied mainly by intranasal or injectable routes in rodent anxiety and memory models.
- Marketed in Russia as an anxiolytic nasal spray.
How it is described to act
- 1
Administered intranasally or by injection in the published studies.
- 2
Reported to reach limbic and hippocampal structures.
- 3
Proposed to modulate BDNF and possibly enkephalinase activity, affecting anxiety-related circuits.
- 4
Observed in rodent models as anxiolytic-like behaviour and reduced ethanol-induced memory impairment.
What the research has looked at
Rodent behavioural pharmacology
- Investigators reported (Bull Exp Biol Med, 2019) that Selank protected against ethanol-induced memory impairment in rats while regulating hippocampal and prefrontal BDNF content.
Mechanism reviews
- A 2018 review in Protein and Peptide Letters summarised the proposed molecular basis of Selank's anxiolytic activity, including tuftsin-receptor-related pathways.
- The same connectomic animal study that examined Semax also compared Selank's network-level brain effects (2020).
Strength of evidence: Preclinical evidence only
Mostly rodent behavioural pharmacology plus Russian clinical registration; no peer-reviewed Western randomised trials were identified.
What is published comes from cell and animal studies. Findings in those models frequently do not carry over to people.
Reported cautions and unknowns
- No independently verified human adverse-event data outside Russian sources were located.
- Because it is unapproved in the US and EU, quality control for internationally sold product is unverifiable.
References
Handling this vial
- Lyophilized vials are generally stored at 2–8 °C and kept out of light; once reconstituted with bacteriostatic water they are refrigerated and commonly discarded after 28 days.
- Mix by aiming water down the vial wall and rolling gently — do not shake — and never re-freeze a reconstituted vial.
- Pep-Tidy cannot verify what is in your vial. Ask your supplier for a current Certificate of Analysis (HPLC/MS).
Selank questions people ask
How do you reconstitute Selank?
A common starting point for a 10 mg vial of Selank is 2 mL of bacteriostatic water, which gives 5 mg per mL. Aim the water down the inside wall of the vial, let it dissolve on its own, and roll gently instead of shaking. Pep-Tidy's reconstitution calculator will recalculate the numbers for any other vial size or water volume you use.
How many units of Selank is one dose?
At 5 mg per mL, that works out to about 6 units on a U-100 insulin syringe for a 300 mcg dose. Change the vial size, water volume, or target dose in the calculator and the syringe reading updates with it. This is arithmetic, not a dosing recommendation.
What dosing schedule is reported for Selank?
Published and community sources describe 250–500 mcg, intranasal / subcutaneous, every day, typically run 2 weeks on and 2 weeks off. These figures describe what has been reported, not what anyone should take — talk to a licensed clinician first.
How should Selank be stored?
Lyophilized Selank vials are generally kept at 2–8 °C and out of light. Once reconstituted with bacteriostatic water they are refrigerated and commonly discarded after about 28 days. Never re-freeze a reconstituted vial and never shake it.
Read this before you act on anything above
Everything on this page is a summary of what other people have published — it is not medical advice, not a recommendation, and not a dosing instruction. Reported dose ranges describe what appears in the literature or in community protocols, not what anyone should take. Talk to a licensed clinician before using any peptide.