Selank
Selank is a synthetic analogue of the immune peptide tuftsin, developed in Russia and studied there as an anxiolytic, with essentially no Western regulatory recognition.
Regulatory status: Registered and used in Russia; not FDA-approved and not reviewed by the EMA. The evidence base is dominated by Russian research groups.
Default vial
10 mg
Default mix
2 mL
Reported range
250–500 mcg
Draw (U-100)
6 u
Anxiolytic tuftsin analog, most often used intranasally in 10–14 day blocks.
What it is
- A synthetic heptapeptide analogue of tuftsin.
- Proposed mechanisms in the Russian pharmacology literature involve BDNF regulation in the hippocampus and prefrontal cortex and inhibition of enkephalin-degrading enzymes.
- Studied mainly by intranasal or injectable routes in rodent anxiety and memory models.
- Marketed in Russia as an anxiolytic nasal spray.
How it is described to act
- 1
Administered intranasally or by injection in the published studies.
- 2
Reported to reach limbic and hippocampal structures.
- 3
Proposed to modulate BDNF and possibly enkephalinase activity, affecting anxiety-related circuits.
- 4
Observed in rodent models as anxiolytic-like behaviour and reduced ethanol-induced memory impairment.
What the research has looked at
Rodent behavioural pharmacology
- Investigators reported (Bull Exp Biol Med, 2019) that Selank protected against ethanol-induced memory impairment in rats while regulating hippocampal and prefrontal BDNF content.
Mechanism reviews
- A 2018 review in Protein and Peptide Letters summarised the proposed molecular basis of Selank's anxiolytic activity, including tuftsin-receptor-related pathways.
- The same connectomic animal study that examined Semax also compared Selank's network-level brain effects (2020).
Strength of evidence: Preclinical evidence only
Mostly rodent behavioural pharmacology plus Russian clinical registration; no peer-reviewed Western randomised trials were identified.
What is published comes from cell and animal studies. Findings in those models frequently do not carry over to people.
Reported cautions and unknowns
- No independently verified human adverse-event data outside Russian sources were located.
- Because it is unapproved in the US and EU, quality control for internationally sold product is unverifiable.
References
Handling this vial
- Lyophilized vials are generally stored at 2–8 °C and kept out of light; once reconstituted with bacteriostatic water they are refrigerated and commonly discarded after 28 days.
- Mix by aiming water down the vial wall and rolling gently — do not shake — and never re-freeze a reconstituted vial.
- Pep-Tidy cannot verify what is in your vial. Ask your supplier for a current Certificate of Analysis (HPLC/MS).
Selank questions people ask
How do you reconstitute Selank?
A common starting point for a 10 mg vial of Selank is 2 mL of bacteriostatic water, which gives 5 mg per mL. Aim the water down the inside wall of the vial, let it dissolve on its own, and roll gently instead of shaking. Pep-Tidy's reconstitution calculator will recalculate the numbers for any other vial size or water volume you use.
How many units of Selank is one dose?
At 5 mg per mL, that works out to about 6 units on a U-100 insulin syringe for a 300 mcg dose. Change the vial size, water volume, or target dose in the calculator and the syringe reading updates with it. This is arithmetic, not a dosing recommendation.
What dosing schedule is reported for Selank?
Published and community sources describe 250–500 mcg, intranasal / subcutaneous, every day, typically run 2 weeks on and 2 weeks off. These figures describe what has been reported, not what anyone should take — talk to a licensed clinician first.
How should Selank be stored?
Lyophilized Selank vials are generally kept at 2–8 °C and out of light. Once reconstituted with bacteriostatic water they are refrigerated and commonly discarded after about 28 days. Never re-freeze a reconstituted vial and never shake it.
Read this before you act on anything above
Everything on this page is a summary of what other people have published — it is not medical advice, not a recommendation, and not a dosing instruction. Reported dose ranges describe what appears in the literature or in community protocols, not what anyone should take. Talk to a licensed clinician before using any peptide.