Pinealon
Glu-Asp-Arg (EDR)
Pinealon is the synthetic tripeptide Glu-Asp-Arg, one of the Khavinson “peptide bioregulators”, studied almost entirely by a single Russian research tradition.
Regulatory status: Not a medicine. No regulator has approved it, and no controlled clinical trial of it has been published.
Default vial
10 mg
Default mix
2 mL
Reported range
No published human dose
Draw (U-100)
20 u
A tripeptide, Glu-Asp-Arg. The published work is overwhelmingly rat and cell-culture studies from one Russian research group; the few papers involving people do not describe a controlled trial.
Where these numbers come from
No published study reports a dose for this compound in people. The figures here exist only so the calculator can run — they are not a recommendation. The Pinealon literature is rat and cell-culture work; the papers involving people do not report a controlled trial.
- Pinealon increases cell viability by suppression of free radical levels, Rejuvenation Res 2011
- Role of mono- and divalent ions in peptide Glu-Asp-Arg–DNA interaction, J Phys Chem B 2019
Reviewed October 2026
What it is
- A three-amino-acid peptide: glutamic acid, aspartic acid, arginine (EDR).
- One of a family of short peptides proposed by their originators to regulate gene expression in specific tissues — in this case the brain.
- Studied in rats by injection; no established human route or schedule.
- Sold as a research compound.
How it is described to act
- 1
No published pharmacokinetic study in people describes how it is absorbed or cleared.
- 2
In laboratory work the peptide has been studied interacting directly with DNA, which is the mechanism its originators propose.
- 3
The hypothesis is that binding in the promoter region influences transcription; this remains a proposal rather than an established pathway.
- 4
In rats this has been associated with changes in behavioural and neurochemical measures.
What the research has looked at
Cell and biophysical work
- Investigators reported that Pinealon reduced free radical levels and increased cell viability in culture, in a dose-dependent way (Rejuvenation Res, 2011).
- A biophysical study examined how the Glu-Asp-Arg peptide interacts with DNA using NMR, viscosimetry and molecular dynamics (J Phys Chem B, 2019).
Animal studies
- In aged rats, researchers compared Pinealon with Cortexin on behaviour and caspase-3 activity after carotid artery occlusion (Adv Gerontol, 2011).
- Further rat work from the same tradition examined behaviour and neurochemistry in 18-month-old animals (Adv Gerontol, 2015).
What is not here
- Two papers describe giving the preparation to people, including a group of railway workers, but neither reports a randomised or placebo-controlled design, so they do not establish an effect.
- The work comes overwhelmingly from one group publishing in a small number of Russian journals, and has not been independently replicated.
Strength of evidence: Preclinical evidence only
The usable evidence is rat and cell-culture work from a single research tradition. The handful of papers involving people do not describe a controlled trial.
What is published comes from cell and animal studies. Findings in those models frequently do not carry over to people.
Reported cautions and unknowns
- No controlled human safety data exists.
- Because the literature is concentrated in one group and one language, there is little independent scrutiny of either the positive findings or the absence of reported harms.
References
- 1.Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes, Rejuvenation Res (2011)
- 2.Role of Mono- and Divalent Ions in Peptide Glu-Asp-Arg–DNA Interaction, J Phys Chem B (2019)
- 3.Effects of short peptides before carotid artery occlusion on behaviour and caspase-3 activity in old rats, Adv Gerontol (2011)
Handling this vial
- Lyophilized vials are generally stored at 2–8 °C and kept out of light; once reconstituted with bacteriostatic water they are refrigerated and commonly discarded after 28 days.
- Mix by aiming water down the vial wall and rolling gently — do not shake — and never re-freeze a reconstituted vial.
- Pep-Tidy cannot verify what is in your vial. Ask your supplier for a current Certificate of Analysis (HPLC/MS).
Pinealon questions people ask
How do you reconstitute Pinealon?
A common starting point for a 10 mg vial of Pinealon is 2 mL of bacteriostatic water, which gives 5 mg per mL. Aim the water down the inside wall of the vial, let it dissolve on its own, and roll gently instead of shaking. Pep-Tidy's reconstitution calculator will recalculate the numbers for any other vial size or water volume you use.
How many units of Pinealon is one dose?
At 5 mg per mL, that works out to about 20 units on a U-100 insulin syringe for a 1000 mcg dose. Change the vial size, water volume, or target dose in the calculator and the syringe reading updates with it. This is arithmetic, not a dosing recommendation.
What dosing schedule is reported for Pinealon?
Published and community sources describe No published human dose, subcutaneous, every day, typically run 0 weeks on. These figures describe what has been reported, not what anyone should take — talk to a licensed clinician first.
How should Pinealon be stored?
Lyophilized Pinealon vials are generally kept at 2–8 °C and out of light. Once reconstituted with bacteriostatic water they are refrigerated and commonly discarded after about 28 days. Never re-freeze a reconstituted vial and never shake it.
Read this before you act on anything above
Everything on this page is a summary of what other people have published — it is not medical advice, not a recommendation, and not a dosing instruction. Reported dose ranges describe what appears in the literature or in community protocols, not what anyone should take. Talk to a licensed clinician before using any peptide.