Kisspeptin-10
Kisspeptin-10 is a fragment of the natural reproductive hormone kisspeptin, studied in controlled infusion experiments for its effects on reproductive hormones and on sexual and emotional brain responses.
Regulatory status: Not approved for any indication and used only in controlled research infusions. As a consumer compound it effectively does not exist legitimately — anything sold outside a research setting is unregulated and unverified.
Default vial
5 mg
Default mix
2 mL
Reported range
~1 mg (research: 25–100 mcg/kg)
Draw (U-100)
40 u
Mostly research protocols; dosing is weight-based in the literature.
What it is
- An endogenous decapeptide fragment of kisspeptin, the KISS1 gene product that regulates GnRH release.
- Acts at the KISS1R (GPR54) receptor.
- Implicated in the timing of puberty; the pathway is studied in central precocious puberty research.
- Human studies use intravenous infusion in clinical research units, not self-administration.
How it is described to act
- 1
Administered by intravenous infusion in research settings.
- 2
Reaches hypothalamic and circumventricular regions accessible to peripherally administered peptides.
- 3
Proposed to act via KISS1R on GnRH neurons and possibly on limbic circuits including the amygdala.
- 4
Observed in fMRI studies as altered brain activity during sexual and emotional stimuli, alongside changes in luteinising hormone.
What the research has looked at
Human infusion and imaging studies
- Comninos et al. (J Clin Invest, 2017) reported that kisspeptin administration modulated brain activity in limbic structures during sexual and emotional processing tasks in men.
Receptor pharmacology and puberty
- Roseweir and Millar (2013) summarised kisspeptin receptor pharmacology and antagonist development for reproductive disorders.
- A 2018 review described kisspeptin signalling's central role in triggering puberty, informing precocious-puberty research.
Strength of evidence: Limited human evidence
Small controlled single-dose human infusion studies exist, but there is no approved product and no large trial base.
Some human data exist, but they are small, short, or not designed to answer the questions people ask online.
Reported cautions and unknowns
- Infusion studies reported no major acute safety signals, but they were short and small.
- No data exist on chronic or self-administered use, and purity or dosing of any non-research product cannot be verified.
References
Handling this vial
- Lyophilized vials are generally stored at 2–8 °C and kept out of light; once reconstituted with bacteriostatic water they are refrigerated and commonly discarded after 28 days.
- Mix by aiming water down the vial wall and rolling gently — do not shake — and never re-freeze a reconstituted vial.
- Pep-Tidy cannot verify what is in your vial. Ask your supplier for a current Certificate of Analysis (HPLC/MS).
Kisspeptin-10 questions people ask
How do you reconstitute Kisspeptin-10?
A common starting point for a 5 mg vial of Kisspeptin-10 is 2 mL of bacteriostatic water, which gives 2.5 mg per mL. Aim the water down the inside wall of the vial, let it dissolve on its own, and roll gently instead of shaking. Pep-Tidy's reconstitution calculator will recalculate the numbers for any other vial size or water volume you use.
How many units of Kisspeptin-10 is one dose?
At 2.5 mg per mL, that works out to about 40 units on a U-100 insulin syringe for a 1000 mcg dose. Change the vial size, water volume, or target dose in the calculator and the syringe reading updates with it. This is arithmetic, not a dosing recommendation.
What dosing schedule is reported for Kisspeptin-10?
Published and community sources describe ~1 mg (research: 25–100 mcg/kg), subcutaneous, twice weekly, typically run 4 weeks on and 4 weeks off. These figures describe what has been reported, not what anyone should take — talk to a licensed clinician first.
How should Kisspeptin-10 be stored?
Lyophilized Kisspeptin-10 vials are generally kept at 2–8 °C and out of light. Once reconstituted with bacteriostatic water they are refrigerated and commonly discarded after about 28 days. Never re-freeze a reconstituted vial and never shake it.
Read this before you act on anything above
Everything on this page is a summary of what other people have published — it is not medical advice, not a recommendation, and not a dosing instruction. Reported dose ranges describe what appears in the literature or in community protocols, not what anyone should take. Talk to a licensed clinician before using any peptide.