DSIP
Delta Sleep-Inducing Peptide
DSIP is a nine-amino-acid peptide first isolated from rabbit brain in the 1970s and proposed to promote slow-wave sleep, though its physiological role has never been resolved.
Regulatory status: Not an approved drug anywhere — no FDA, EMA or Russian registration. It exists only as a research peptide.
Default vial
5 mg
Default mix
2 mL
Reported range
100–300 mcg
Draw (U-100)
8 u
Taken shortly before bed; some run it every other night.
What it is
- A nonapeptide originally isolated from the cerebral venous blood of sleep-deprived rabbits.
- Its receptor is unidentified; no confirmed cognate receptor has been established in the literature.
- Studied mostly in animal EEG and sleep-latency models rather than human trials.
- Recent published work uses it as a model peptide in drug-delivery materials science rather than pharmacology.
How it is described to act
- 1
Given intravenously or intraperitoneally in the animal studies that exist; reported to enter circulation quickly.
- 2
Thought to reach the central nervous system, though transport mechanisms are not well characterised.
- 3
Proposed but unconfirmed interactions include modulation of GABAergic and opioid-like sleep-regulatory circuits.
- 4
Observed mainly as EEG slow-wave changes in older animal studies, with inconsistent replication in humans.
What the research has looked at
Early isolation and physiology
- In a 1986 update review in Peptides, Graf and Kastin summarised DSIP's isolation and the inconsistent sleep-promoting effects reported across species.
Modern use in delivery science
- Researchers studying macroporous polymer matrices (2014) used DSIP as a model peptide for controlled-release entrapment, making no new pharmacological claims.
Strength of evidence: Preclinical evidence only
Findings are confined to older animal work and a handful of small, inconsistent human studies from decades ago. There is no modern human clinical trial base.
What is published comes from cell and animal studies. Findings in those models frequently do not carry over to people.
Reported cautions and unknowns
- No systematic human safety data exist; anecdotal reports from unregulated products cannot be verified.
- Because it is unregulated, purity and dosing of anything sold online cannot be assured.
References
Handling this vial
- Lyophilized vials are generally stored at 2–8 °C and kept out of light; once reconstituted with bacteriostatic water they are refrigerated and commonly discarded after 28 days.
- Mix by aiming water down the vial wall and rolling gently — do not shake — and never re-freeze a reconstituted vial.
- Pep-Tidy cannot verify what is in your vial. Ask your supplier for a current Certificate of Analysis (HPLC/MS).
DSIP questions people ask
How do you reconstitute DSIP?
A common starting point for a 5 mg vial of DSIP is 2 mL of bacteriostatic water, which gives 2.5 mg per mL. Aim the water down the inside wall of the vial, let it dissolve on its own, and roll gently instead of shaking. Pep-Tidy's reconstitution calculator will recalculate the numbers for any other vial size or water volume you use.
How many units of DSIP is one dose?
At 2.5 mg per mL, that works out to about 8 units on a U-100 insulin syringe for a 200 mcg dose. Change the vial size, water volume, or target dose in the calculator and the syringe reading updates with it. This is arithmetic, not a dosing recommendation.
What dosing schedule is reported for DSIP?
Published and community sources describe 100–300 mcg, subcutaneous, every day, typically run 4 weeks on and 2 weeks off. These figures describe what has been reported, not what anyone should take — talk to a licensed clinician first.
How should DSIP be stored?
Lyophilized DSIP vials are generally kept at 2–8 °C and out of light. Once reconstituted with bacteriostatic water they are refrigerated and commonly discarded after about 28 days. Never re-freeze a reconstituted vial and never shake it.
Read this before you act on anything above
Everything on this page is a summary of what other people have published — it is not medical advice, not a recommendation, and not a dosing instruction. Reported dose ranges describe what appears in the literature or in community protocols, not what anyone should take. Talk to a licensed clinician before using any peptide.