Gonadorelin
GnRH, LHRH
Gonadorelin is synthetic GnRH, the hypothalamic hormone that tells the pituitary to release LH and FSH. It has a real but largely historical human approval record in the US.
Regulatory status: Complicated. Human products were approved in the US — Factrel in 1982 for diagnostic use and Lutrepulse in 1989 for ovulation induction — but the product currently listed under the Factrel name is a cattle medicine.
Default vial
2 mg
Default mix
2 mL
Reported range
100 mcg (diagnostic label dose)
Draw (U-100)
10 u
The natural hypothalamic hormone that tells the pituitary to release LH and FSH. It has a real human approval history in the US — as a diagnostic agent and, as Lutrepulse, for ovulation induction — but the product currently listed under the Factrel name is a cattle medicine.
Where these numbers come from
The 100 mcg figure is the diagnostic dose from gonadorelin's US human labelling (Factrel, approved 1982 for diagnostic use; Lutrepulse, 1989, for ovulation induction by pump). No label defines the repeated self-administered dosing discussed in community protocols.
- FDA — gonadorelin / Lutrepulse orphan drug designation record
- DailyMed — Factrel (gonadorelin) current label
Reviewed October 2026
What it is
- A ten-amino-acid peptide identical to natural gonadotropin-releasing hormone.
- Acts on the pituitary, which in turn acts on the testes or ovaries — the top of the reproductive hormone axis.
- Very short-acting: natural GnRH is released in pulses and cleared within minutes, which is why the approved ovulation-induction product used a pump rather than injections.
- Not the same as the long-acting GnRH agonists used in prostate cancer, which deliberately shut the axis down.
How it is described to act
- 1
Given by injection or infusion; broken down within minutes.
- 2
Reaches the anterior pituitary and binds GnRH receptors there.
- 3
A pulse triggers LH and FSH release. Continuous exposure does the opposite — it desensitises the receptor and suppresses the axis, which is the basis of the cancer drugs.
- 4
Downstream, LH and FSH act on the gonads to drive testosterone or follicular development.
What the research has looked at
Approved human uses
- According to FDA records, gonadorelin was approved for diagnostic use in evaluating pituitary gonadotropin reserve, and the Lutrepulse product carried an orphan designation for inducing ovulation in women with hypothalamic amenorrhoea.
- The ovulation product was administered by a programmed pump reproducing the natural pulse pattern — a detail that matters, because the whole point was pulsatile delivery.
What the label does not cover
- No human label defines the repeated self-administered dosing used in community protocols for keeping the testicular axis running.
- The pulse-versus-continuous distinction means dosing schedule is not a detail here: the wrong pattern produces the opposite effect to the one intended.
Strength of evidence: Approved drug (for a specific indication)
There is genuine approved human use behind this molecule, but it is diagnostic and pump-delivered fertility use, not the ongoing self-administered use discussed online.
This molecule is an approved medicine for at least one indication. Where that is the case, the approved prescribing information — not community convention — governs its use.
Reported cautions and unknowns
- Approved use was short-term and supervised, so the safety record does not describe continuous self-administration.
- Sustained non-pulsatile exposure suppresses the reproductive axis rather than supporting it — the opposite of the usual goal.
- Anyone using this to manage a hormone axis is doing something a blood test can actually measure; doing it without measuring is guesswork.
References
Handling this vial
- Lyophilized vials are generally stored at 2–8 °C and kept out of light; once reconstituted with bacteriostatic water they are refrigerated and commonly discarded after 28 days.
- Mix by aiming water down the vial wall and rolling gently — do not shake — and never re-freeze a reconstituted vial.
- Pep-Tidy cannot verify what is in your vial. Ask your supplier for a current Certificate of Analysis (HPLC/MS).
Gonadorelin questions people ask
How do you reconstitute Gonadorelin?
A common starting point for a 2 mg vial of Gonadorelin is 2 mL of bacteriostatic water, which gives 1 mg per mL. Aim the water down the inside wall of the vial, let it dissolve on its own, and roll gently instead of shaking. Pep-Tidy's reconstitution calculator will recalculate the numbers for any other vial size or water volume you use.
How many units of Gonadorelin is one dose?
At 1 mg per mL, that works out to about 10 units on a U-100 insulin syringe for a 100 mcg dose. Change the vial size, water volume, or target dose in the calculator and the syringe reading updates with it. This is arithmetic, not a dosing recommendation.
What dosing schedule is reported for Gonadorelin?
Published and community sources describe 100 mcg (diagnostic label dose), subcutaneous, every day, typically run 4 weeks on. These figures describe what has been reported, not what anyone should take — talk to a licensed clinician first.
How should Gonadorelin be stored?
Lyophilized Gonadorelin vials are generally kept at 2–8 °C and out of light. Once reconstituted with bacteriostatic water they are refrigerated and commonly discarded after about 28 days. Never re-freeze a reconstituted vial and never shake it.
Read this before you act on anything above
Everything on this page is a summary of what other people have published — it is not medical advice, not a recommendation, and not a dosing instruction. Reported dose ranges describe what appears in the literature or in community protocols, not what anyone should take. Talk to a licensed clinician before using any peptide.