Epitalon
Epithalon
Epitalon is a synthetic four-amino-acid peptide (Ala-Glu-Asp-Gly) modelled on a pineal-gland extract and promoted for anti-ageing effects, with very little peer-reviewed human evidence behind it.
Regulatory status: Not approved by the FDA or any major Western regulator. It has never completed a registered Western clinical trial and is sold in the US only as a research chemical.
Default vial
50 mg
Default mix
5 mL
Reported range
5–10 mg
Draw (U-100)
50 u
Classic Khavinson pattern: a 10–20 day course, one or two courses per year.
What it is
- A synthetic tetrapeptide (Ala-Glu-Asp-Gly), a shorter analogue of epithalamin, a peptide originally extracted from bovine pineal gland.
- Most foundational research comes from Russian laboratories, much of it published in Russian-language or smaller international journals.
- Studied mainly in rodent, cell-culture and oocyte-ageing models via injection.
- Only a handful of relatively recent English-language peer-reviewed studies exist.
How it is described to act
- 1
Injected in the studies located; rigorous human pharmacokinetic data appear to be absent from the literature.
- 2
Preclinical work suggests involvement of the pineal gland and hypothalamic-pituitary axis, based on the compound's origin.
- 3
In vitro studies report gene-expression and telomerase-related effects, with authors proposing an epigenetic mechanism.
- 4
Studied for oocyte-ageing protection in mice and general geroprotective effects in animal models; human clinical outcome data are essentially absent.
What the research has looked at
Recent mechanistic and cell studies
- A 2020 paper in Molecules reported that the AEDG peptide stimulated gene expression and protein synthesis during neurogenesis in vitro, proposing an epigenetic mechanism.
- A 2022 study in Aging reported that Epitalon protected against post-ovulatory ageing-related damage in mouse oocytes in vitro.
The older Russian literature
- Publications from Russian peptide-bioregulator groups reported life-extension and telomerase-activation effects in animal models. This body of work underpins most Epitalon marketing but is not well replicated in independent Western peer review, and much of it is not indexed or translated.
Strength of evidence: Preclinical evidence only
Bluntly: the evidence is thin. A small number of animal and in-vitro studies plus older, poorly replicated Russian-language work, with essentially no rigorous human clinical outcome data.
What is published comes from cell and animal studies. Findings in those models frequently do not carry over to people.
Reported cautions and unknowns
- No FDA-reviewed human safety data exist, and the research-chemical market provides no verified purity or dosing consistency.
- The available studies are short-duration animal and cell experiments, so long-term human safety is unknown rather than reassuring.
References
Handling this vial
- Lyophilized vials are generally stored at 2–8 °C and kept out of light; once reconstituted with bacteriostatic water they are refrigerated and commonly discarded after 28 days.
- Mix by aiming water down the vial wall and rolling gently — do not shake — and never re-freeze a reconstituted vial.
- Pep-Tidy cannot verify what is in your vial. Ask your supplier for a current Certificate of Analysis (HPLC/MS).
Epitalon questions people ask
How do you reconstitute Epitalon?
A common starting point for a 50 mg vial of Epitalon is 5 mL of bacteriostatic water, which gives 10 mg per mL. Aim the water down the inside wall of the vial, let it dissolve on its own, and roll gently instead of shaking. Pep-Tidy's reconstitution calculator will recalculate the numbers for any other vial size or water volume you use.
How many units of Epitalon is one dose?
At 10 mg per mL, that works out to about 50 units on a U-100 insulin syringe for a 5000 mcg dose. Change the vial size, water volume, or target dose in the calculator and the syringe reading updates with it. This is arithmetic, not a dosing recommendation.
What dosing schedule is reported for Epitalon?
Published and community sources describe 5–10 mg, subcutaneous, every day, typically run 2 weeks on and 24 weeks off. These figures describe what has been reported, not what anyone should take — talk to a licensed clinician first.
How should Epitalon be stored?
Lyophilized Epitalon vials are generally kept at 2–8 °C and out of light. Once reconstituted with bacteriostatic water they are refrigerated and commonly discarded after about 28 days. Never re-freeze a reconstituted vial and never shake it.
Read this before you act on anything above
Everything on this page is a summary of what other people have published — it is not medical advice, not a recommendation, and not a dosing instruction. Reported dose ranges describe what appears in the literature or in community protocols, not what anyone should take. Talk to a licensed clinician before using any peptide.